The crash took place around 10:46 a.m., Wednesday, May 8, near Main Street in Peekskill, said Peekskill Police Det. Sgt. Jack Galusha.
"We are still trying to sort out this mess, but thanks goodness there were no fatalities," Galusha said.
Numerous people were injured, but Galusha did not have a number of how many. He also said that some had to be rescued from one of the vehicles which burst into flames.
Emergency workers crowded the area to help the wounded, and fire officials worked to remove those from the burning vehicle, he added.
The roadway has finally been cleared, but motorists are asked to avoid the area for a short time as things are "sorted out," police said.
The crash comes on the heels of an earlier serious crash also on Route 9 in Poughkeepsie that involved a single-vehicle motorcycle crash with serous injuries, Galusha said.
This is a developing story. Check back to Daily Voice for updates.
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